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Coming up: Sat 31 Oct · Frontier Paper Club: DeepSeek-R1: reasoning learned through reinforcement learning; Wed 4 Nov · Build Night: Agents for Science: Build a literature agent that cites its sources; Sat 7 Nov · Frontier Paper Club: AI Co-Scientist: multi-agent hypothesis generation; Sat 14 Nov · Frontier Paper Club: Language agents that synthesise scientific knowledge; Sun 15 Nov · GPU 101: From Notebook to Accelerator: Profile a PyTorch training loop on a free GPU; Wed 18 Nov · Build Night: Agents for Science: Score genetic variants with Evo 2

Signal from Srikakulam

The AI and life-science frontier in plain language: what changed, why it matters, and one thing you can try. Free, no tracking pixels, unsubscribe any time.

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Inside every issue

  1. 1

    The frontier

    One change in compute or models, from NVIDIA’s roadmap to the newest open weights, explained.

  2. 2

    Try this

    A small hands-on exercise you can run in a free notebook in under an hour.

  3. 3

    Paper Club pick

    The paper we are reading next, with a guide to the parts worth your time.

  4. 4

    Clinical corner

    A note from our clinical advisory on evidence, safety, and what holds up at the bedside.

Sample issues

Previews of the kind of issues we write. The first edition goes to subscribers.

  • Why your GPU sits idle

    Preview

    Memory bandwidth, not FLOPs, is usually the bottleneck. A tour from Blackwell to Rubin, and what it means for a free cloud notebook.

    • The frontier: NVIDIA’s roadmap in one chart
    • Try this: profile a PyTorch loop
    • From the lab: Build Night notes

  • Reasoning models, explained without hype

    What o1, DeepSeek-R1, and their successors actually do differently, and where they still fail on science questions.

    • The frontier: test-time compute
    • Paper Club pick: DeepSeek-R1
    • Clinical corner: when “thinking” is not evidence

  • From AlphaFold to Evo 2

    Two years of biology foundation models, and the open tools a student in Srikakulam can run this weekend.

    • The frontier: structure and sequence models
    • Try this: score a variant
    • Programs: next Open Data Sprint

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